What is loratadine and pseudoephedrine, and how does it work (mechanism of action)?
Loratadine/pseudoephedrine is a combination of two drugs, an antihistamine (loratadine) and a decongestant (pseudoephedrine). Loratadine is a long-acting antihistamine that blocks the actions of histamine that causes some of the symptoms of allergic reactions. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine on their surfaces. Histamine stimulates the cells to release chemicals that produce effects that are associated with
allergy symptoms. Loratadine blocks one type of histamine receptor (the H1 receptor) and thus prevents activation of cells with H1 receptors by histamine. Unlike some antihistamines, loratadine does not enter the brain from the blood and, therefore, does not cause drowsiness when taken at recommended doses. It is one of a few antihistamines that do not cause sedation. Pseudoephedrine decongests tissues by causing blood vessels to constrict.
What brand names are available for loratadine and pseudoephedrine?
Alavert Allergy & Sinus, Claritin-D, Claritin-D 24 hour, and many others
Is loratadine and pseudoephedrine available as a generic drug?
Do I need a prescription for loratadine and pseudoephedrine?
What are the side effects of loratadine and pseudoephedrine?
Side effects of loratadine/pseudoephedrine include:
Medically Reviewed by a Doctor on 5/11/2017
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.