GENERIC NAME: lidocaine and prilocaine

BRAND NAME: DermacinRx, Prizopak, EMLA, Leva Set, Lidopril, Livixil Pak, LP Lite Pak, Oraqix, Relador Pak, Venipuncture CPI



USES: Lidocaine and prilocaine cream is commonly used as a local
anesthetic on normal intact skin and genital mucous areas, before minor

SIDE EFFECTS: Common side effects of lidocaine and prilocaine are:

  • application site redness,
  • pain,
  • burning,
  • paleness,
  • edema, and
  • altered temperature sensation.

Other rare side effects include:

  • shock,
  • central nervous system depression,
  • hypersensitivity reactions, and
  • hypotension (low blood pressure).

PREPARATIONS: Lidocaine and prilocaine is a combination cream, containing
2.5% of each component. Lidocaine and prilocaine is available in 5 gram and 30
gram tubes.

DRUG INTERACTIONS: Lidocaine and prilocaine should not be used together with
anti-arrhythmic drugs such as tocainide (Tonocard) and mexiletine (Mexitil), due to additive effects
on heart rate and rhythm.

Prilocaine may contribute to formation of methemoglobin in patients treated
with other drugs known to cause methemoglobinemia.

Lidocaine and prilocaine should be used with caution with anti-arrhythmic
drugs like
(Cordarone), sotalol (Betapace), bretylium, and dofetilide (Tikosyn) because of increased
risk developing abnormal heart rate and rhythm.

Medically Reviewed by a Doctor on 8/1/2016

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