What is fluphenazine-oral, and how does it work (mechanism of action)?

Fluphenazine is an oral antipsychotic medication
used for the management of schizophrenia. Fluphenazine is one of the older,
first-generation piperazine phenothiazine antipsychotic medications. Examples of
other phenothiazines include:

Although the exact mechanism of phenothiazine
antipsychotics is unknown, scientists believe that they may work by blocking the
action of dopamine in the brain. Dopamine is a neurotransmitter (chemical) that
nerves use to communicate with one another. Phenothiazine antipsychotics are
used when patients do not respond to other antipsychotics.

The FDA approved fluphenazine in September 1959.

What brand names are available for fluphenazine-oral?

Permitil, Prolixin

Is fluphenazine-oral available as a generic drug?


Do I need a prescription for fluphenazine-oral?


What are the side effects of fluphenazine-oral?

Fluphenazine causes extrapyramidal side effects such as:

  • Abnormal muscle contractions
  • Difficulty breathing and
  • Neck spasms

Other side effects include:

Tardive dyskinesia (movement abnormalities of the face, arms, and legs)
can result from fluphenazine treatment.

Neuroleptic malignant syndrome (NMS) which includes symptoms such as fever,
muscle rigidity, altered mental status, irregular blood pressure, and irregular
heart rate and rhythm can occur. These side effects can be severe so patients
must seek medical help.

Elderly patients with
psychosis treated with antipsychotics are at an increased risk of death, and
fluphenazine should not be used for treating patients with dementia related

Medically Reviewed by a Doctor on 5/12/2017

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